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Evaluation of cardiac function in patients with major beta thalassemia in Birjand
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T. Chahkandi   , T. Kazemi , A. Jalili , F. Ghaderi |
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| Keywords: Key words: beta-Thalassemia, Electrocardiography, Radiography, Echocardiography |
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Type of Study: Research |
Subject:
Hematology
Published: 2013/08/14
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Full-Text: (2354 Views) |
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Sci J Iran Blood Transfus Organ 2013; 10 (1): 86-92
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Evaluation of cardiac function in patients with
major beta thalassemia in Birjand
Chahkandi T.1, Kazemi T.1, Jalili A.2, Ghaderi F.3
1Birjand Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran
2Birjand Research Committee. Birjand University of Medical Sciences, Birjand, Iran
3Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background and Objectives
The most common leading causes of death in patients with major beta thalassemia are cardiac complications.The purpose of this study is to determine cardiac function in patients with major thalassemia in Birjand.
Materials and Methods
This descriptive-analytical study was conducted on all patients with major beta thalassemia having referred to special clinics of Valiasr Hospital in Birjand. Variables such as age, sex, frequency of transfusions, serum ferritin, and hemoglobin were studied. For all patients after a thorough examination of heart, ECG, chest X-ray, and echocardiography were performed. All data were collected and analyzed with SPSS software 15.5 by t-test at α ≤ 0.05.
Results
We studied 35 patients with major beta thalassemia. The mean age was 9.06 ± 4.33 years. The mean hemoglobin was 9.2 gr/dl and the mean ferritin 2121.6 ng/ml, respectively. Cardiac examinations showed 62.9% of patients to be normal. ECG and chest X-ray in 71.6% and 57.1% of patients were normal, respectively. Out of the total number of patients, 77.8% had abnormal echocardiography. The most common abnormal findings in echocardiography were restrictive diastolic dysfunction. No significant correlation was found between abnormal findings on echocardiography with both ferritin and the number of blood transfusions. However, left ventricular diastolic dysfunction and hemoglobin were not significantly associated (8.5 ± 0.69 gr/dL in normal diastolic function, 9.6 ± 0.99 gr/dL in diastolic dysfunction p= 0.007).
Conclusions
The most common finding in our study was left ventricular diastolic dysfunction. Therefore, periodic echocardiography to determine the risk of heart involvement is very valuable.
Key words: beta-Thalassemia, Electrocardiography, Radiography, Echocardiography
Received: 19 May 2012
Accepted: 21 Aug 2012
Correspondence: Kazemi T., MD. Associate Professor of Cardiology. Birjand Atherosclerosis and Coronary Artery Research Center of Birjand University of Medical Sciences. Valiasr Hospital, Ghaffari St.
Postal Code: 9717964151, Birjand, Iran. Tel: (+98561) 4443001; Fax: (+98561) 4433004
E-mail: med_847@yahoo.com
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Chahkandi T, Kazemi T, Jalili A, Ghaderi F. Evaluation of cardiac function in patients with major beta thalassemia in Birjand. Sci J Iran Blood Transfus Organ 2013; 10 (1) :86-92 URL: http://bloodjournal.ir/article-1-742-en.html
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