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:: Volume 9, Issue 2 (Summer 2012) ::
Sci J Iran Blood Transfus Organ 2012, 9(2): 140-148 Back to browse issues page
Immunophenotyping assessment of Acute Lymphoid Leukemia in adults and its relation to induction therapy
SH. Chavoshi , J. Eivazi Ziaei , A.A. Movasaghpour , R. Dolatkhah
Abstract:   (19649 Views)

  Abstract

 Background and Objectives

  Acute Lymphoblastic Leukemia (ALL) is associated with a high rate of mortality in adults and the cure rate of the affected patients is nearly 25-40%. In order to achieve a good treatment, diagnosis of ALL subtypes and their consequent differentiation from other types of leukemia are required. The main aim of this study was to classify ALL subtypes by Flowcytometry.

 

 Materials and Methods

  One hundred and thirty four patients with ALL were recruited from Shahid Ghazi Hospital (1998 to 2006). In these studies, 86 out of 134 patients were examined by Flowcytometry.

 

 Results

 About 15.5% of the patients were considered to have pro B-cell ALL, 52% pre B-cell and mature B-cell ALL, and 32% mature T-cell ALL 64% of the patients with B-cell subtype achieved complete remission after induction therapy, while this percentage for T-cell ALL was 44%. Based on the examined markers, the differentiation of Pre T-cell ALL from mature T-cell ALL was not possible. The response to therapy was higher in the T-cell ALL group compared to B-cell.

 

 Conclusions

  In this study, the frequency of T-cell ALL was higher than the reference (32%). However, it must be mentioned that the high grade T-cell Lymphoma was differentiated from ALL. The duration of remission and survival in B-cell ALL was longer than T-cell ALL but this difference was not statistically significant.

  

 

Keywords: Lymphoblastic Leukemia, Acute, Immunophenotyping, Induction of Remission
Full-Text [PDF 233 kb]   (5711 Downloads)    
Type of Study: Research | Subject: Hematology
Published: 2013/08/27
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Chavoshi S, Eivazi Ziaei J, Movasaghpour A, Dolatkhah R. Immunophenotyping assessment of Acute Lymphoid Leukemia in adults and its relation to induction therapy. Sci J Iran Blood Transfus Organ 2012; 9 (2) :140-148
URL: http://bloodjournal.ir/article-1-648-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 2 (Summer 2012) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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