Comparison of cell counter indices in differentiation of beta thalassemia minor from iron deficiency anemia
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Ghafouri M. , Mostaan Sefat L. , Sharifi Sh. , Hosseini Gohari L. , Attarchi Z. |
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Abstract: (58881 Views) |
Abstract Background and Objectives Distinguishing two common hypochromic microcytic anemias (i.e. iron deficiency anemia and minor thalassemia) needs expensive laboratory tests not readily available everywhere. A number of indices derived from original cell counter parameters were tried to screen patients these indices are compared in this study. Materials and Methods Four indices of England, Mentzer, Shine and MDHL were calculated for 110 cases of known thalassemia minors and 61 iron deficients. The best cut-off point for each index was selected by receiver operator characteristic (ROC) analysis reaching the highest sensitivity to separate thalassemics from iron deficients. Sensitivity and specificity of indices were compared.� Results Mentzer’s index(sensitivity:90.9, specificity:80.3) had the best results. Conclusions It seems Mentzer’s index can be used widely to screen hypochromic microcytic anemic patients. Tests like hemoglobin electrophoresis, genetic studies, serum iron, TIBC and ferritin measurement should be reserved for selected patients in refferal centers. In this way we reduce public health costs significantly. Key words : Differential diagnosis, Minor thalassemia, Iron deficiency |
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Keywords: Differential diagnosis, Minor thalassemia, Iron deficiency |
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Full-Text [PDF 218 kb]
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Type of Study: Research |
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General Published: 2014/08/19
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