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:: Volume 18, Issue 4 (Winter 2021) ::
Sci J Iran Blood Transfus Organ 2021, 18(4): 279-290 Back to browse issues page
Apoptosis as a marker of platelet storage lesion
F. Kiani Nodeh , M. Ghasemzadeh , E. Hosseini
Keywords: Key words: Apoptosis, Blood, Platelets, Blood Transfusion
Full-Text [PDF 508 kb]   (881 Downloads)     |   Abstract (HTML)  (1248 Views)
Type of Study: Review Article | Subject: Blood Transfusion
Published: 2021/12/31
Full-Text:   (4042 Views)
    
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Sci J Iran Blood Transfus Organ 2021;18 (4): 279-290
Original Article
 
 
 
 
 


Apoptosis as a marker of platelet storage lesion 
 
Kiani Nodeh F.1, Ghasemzadeh M.1, Hosseini E. 1
 
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
 
 
 
Abstract
Background and Objectives
During storage, platelets may lose their functional capability and structural integrity. This process is often called as "platelet storage lesion" (PSL), which is characterized with changes in morphology, metabolism, membrane structure, and expression of platelet activation and apoptotic markers. Apoptosis, or programmed cell death, is an energy-dependent physiological mechanism that results in the controlled removal of unwanted or damaged cells. While it has long been attributed exclusively to nucleated cells, many studies demonstrated that apoptosis also occurs in anucleate cells and platelets.
 
Materials and Methods
Studies published in MEDLINE, PubMed, and Google scholar are assessed for keywords and 55 articles is cited
 
Results
The present review article describes the different apoptosis pathways in platelets, while adressing the markers, methods and probes used for evaluating apoptosis in platelet concentrates.
 
Conclusions 
The evaluation of apoptosis can play an important role in identifying the mechanisms involved in platelet storage lesion.
 
Key words: Apoptosis, Blood, Platelets, Blood Transfusion
 
 
 
 
 
 
 
 
 
 
 
 
 
Received:  30 May 2021
Accepted: 22 Aug 2021
 
 

Correspondence: Hosseini E., PhD in Hematology. Associate Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88699531; Fax: (+9821) 88699531
E-mail:
e.hosseini10@yahoo.com.au
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Kiani Nodeh F, Ghasemzadeh M, Hosseini E. Apoptosis as a marker of platelet storage lesion. Sci J Iran Blood Transfus Organ 2021; 18 (4) :279-290
URL: http://bloodjournal.ir/article-1-1411-en.html
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Volume 18, Issue 4 (Winter 2021) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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