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:: Volume 17, Issue 3 (Autumn 2020) ::
Sci J Iran Blood Transfus Organ 2020, 17(3): 226-241 Back to browse issues page
Advances and challenges in storage, transplantation, expansion and homing of Umbilical Cord Blood Hematopoietic Stem Cells (UCB-HSCs)
V. Niazi , S. Heydari Keshel , M. Shahbazi
Keywords: Key words: Umbilical Cord Blood, Hematopoietic Stem Cells, Transplantation
Full-Text [PDF 838 kb]   (766 Downloads)     |   Abstract (HTML)  (2031 Views)
Type of Study: Review Article | Subject: Stem cells
Published: 2020/10/1
Full-Text:   (1865 Views)
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Sci J Iran Blood Transfus Organ 2020;17 (3); 226-241
Review  Article
 
 
 

Advances and challenges in storage, transplantation,
expansion and homing of Umbilical Cord Blood
Hematopoietic Stem Cells (UCB-HSCs)
 
Niazi V.1, Heidari Keshel S.1, Shahbazi M.2
 
 
 
1Medical Nanotechnology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
 
 
 
Abstract
Background and Objectives
Umbilical cord blood hematopoietic stem cells (UCB-HSCs) have high potential capabilities in the treatment of hematological and non-hematological disorders. Awareness of biology, self-renewal, homing, expansion, storage, and transplantation can lead to optimal use of these cells.
 
Materials and Methods
In this Review article in order to investigate the advances and challenges in cord blood banks, the expansion, storage, homing and transplantation of umbilical cord blood stem cells, we used key words like umbilical cord blood, hematopoietic stem cells and stem cell banks for searching published articles in the PubMed database during 2000 to 2020.
 
Results
Over time, many advances in biology, expansion, storage, and transplantation of cord blood cells have been made by researchers around the world with a growth in the number of private and public cord blood banks in parallel. Despite these advances, there are still challenges to the optimal use of these cells.
 
Conclusions 
Increasing our awareness about the achievements and shortcomings in the area of UCB-HSCs, can lead to the formation of new strategies and further studies for the optimal use of these cells.
 
Key words: Umbilical Cord Blood, Hematopoietic Stem Cells, Transplantation
 
 
 
 
 
 
 
Received:   1  Jan  2020
Accepted: 18 May 2020
 
 

Correspondence: Heidari Keshel S., PhD of Proteomics. Assistant Professor of Medical Nanotechnology Research Center, Shahid Beheshti University of Medical Sciences.
Postal Code: 1985711151, Tehran, Iran. Tel: (+9821) 22714248;  Fax: (+9821) 22714248
E-mail: saeedhey@gmail.com
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Niazi V, heydari Keshel S, Shahbazi M. Advances and challenges in storage, transplantation, expansion and homing of Umbilical Cord Blood Hematopoietic Stem Cells (UCB-HSCs). Sci J Iran Blood Transfus Organ 2020; 17 (3) :226-241
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