[Home ] [Archive]   [ فارسی ]  
:: Main :: About us :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Issue 1 (Spring 2020) ::
Sci J Iran Blood Transfus Organ 2020, 17(1): 1-11 Back to browse issues page
Update on HCV genotypes among Iranian blood donors
F. Ranjbar Kermani Dr., S. Amini Kafi Abad Dr. , K. Mousavi Hosseini Dr., M. Maghsudlu Dr., Z. Sharifi Dr.
Abstract:   (2050 Views)
Background and Objectives
Hepatitis C (HCV) infection is one of the main causes of chronic hepatitis diseases all over the world. HCV is a transfusion transmitted virus and a serious threat to general health. HCV genotyping has an important role in tracing routes of infection. This study aimed at investigating the changes in  distribution pattern of HCV genotypes among Iranian blood donors.
Materials and Methods
In this cross sectional study, 239 HCV confirmed blood donors from Jun. 2015 to Nov. 2017 were included. Semi nested PCR method was used for amplifying the NS5B  region of HCV genome. PCR products were sequenced and HCVgenotypes were determined by searching the sequences in Basic Local Alignment Search Tool (BLAST). Phylogenetic tree was constructed to confirm HCV genotypes. STATA 13 software was used for data analysis. 
In 106 (44.35% ± 6.3%) out of 239 participants, HCV genotype was determined and confirmed. In phylogenetic tree, studied sequences formed three separated clusters. Genotype 3a, 1a and 1b were the common genotypes.
It seems that molecular epidemiology of HCV infection did not change based on variability of genotypes but changes in the frequency of genotypes have been occurred as a result of replacement of genotype 1a by genotype 3a during the last decade among Iranian blood donors.
Keywords: Hepatitis C, Genotype, Blood Donors
Full-Text [PDF 509 kb]   (315 Downloads) |   |   Full-Text (HTML)  (593 Views)  
Type of Study: Research | Subject: Blood transfusion medicine
Published: 2020/03/16
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ranjbar Kermani F, Amini Kafi Abad S, Mousavi Hosseini K, Maghsudlu M, Sharifi Z. Update on HCV genotypes among Iranian blood donors. Sci J Iran Blood Transfus Organ. 2020; 17 (1) :1-11
URL: http://bloodjournal.ir/article-1-1299-en.html

Volume 17, Issue 1 (Spring 2020) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 4319