Abstract
Background and Objectives
Hemophilia is one of the chronic disorders of blood coagulation which due to the lack of coagulation factors exposes the person to a variety of physical problems which affect patient. The effectiveness of cognitive-behavioral therapy and treatment based on acceptance and commitment in adherence to treatment, illness perception and quality of life in hemophilic patients was studied in Isfahan city in 1396.
 
Materials and Methods
This research was semi-experimental with pre-test and post-test design with control group and follow-up periods. To do the research, 60 hemophilic patients were selected based on eligibility criteria in three groups. The research instrument was a questionnaire for Broadbent questionnaire of illness perception, quality of life and Mariski treatment adherence questionnaire. The statistical analysis was done by SPSS 22 and at two descriptive and inferential levels.
 
Results
The results of repeated analysis of variance showed that the difference between the mean scores of the two groups of cognitive-behavioral therapy and the control group was significant in the three variables of treatment adherence, illness perception and quality of life (p <  0.05) and the difference between the mean scores of the two groups of the treatment based on acceptance and commitment and the control group were similarly significant in the three variables of treatment adherence, illness perception and quality of life (p < 0.05).
 
Conclusions 
The results showed that the two cognitive-behavioral treatments and acceptance and commitment therapy could be used to increase adherence to treatment, illness perception and quality of life in patients with hemophilia.