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Frequency of Pulmonary Hypertension among patients with Major Thalassemia in Sanandaj Besat Hospital, 2014-2015
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Borhan Moradveisi    , Mohsen Shahidi , Siamak Vahedi , Parin Yazdanifard , Mohsen Sohrabi , Nima Naleini |
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| Keywords: Key words: beta-Thalassemia, Pulmonary Hypertension, Thrombocytosis, Splenectomy |
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Type of Study: Research |
Subject:
Hematology
Published: 2018/12/4
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Full-Text: (1865 Views) |
References:
- Rezaee AR, Banoei MM, Khalili E, Houshmand M. Beta-thalassemia in Iran: New insight into the role of genetic admixture and migration. Scientific WorldJournal 2012; 2012: 635183.
- Abolghasemi H, Eshghi P. Comprehensive Textbook of Thalassemia. Tehran: Baqiyatallah University of Medical Sciences; 2004. p. 321-79. [Persian]
- Aessopos A, Farmakis D, Karagiorga M, Voskaridou E, Loutradi A, Hatziliami A, et al. Cardiac involvement in thalassemia intermedia: a multicenter study. Blood 2001; 97(11): 3411-6.
- Du ZD, Roguin N, Milgram E, Saab K, Koren A. Pulmonary hypertension in patients with thalassemia major. Am Heart J 1997; 134(3): 532-7.
- Rafsanjani KA, Mafi N, Tafreshi RI. Complications of β-thalassemia intermedia in Iran during 1996-2010 (single-center study). Pediatr Hematol Oncol 2011; 28 (6): 497-508.
- Kiter G, Balci YI, Ates A, Hacioglu S, Sari I. Frequency of pulmonary hypertension in asymptomatic β-thalassemia major patients and the role of physiological parameters in evaluation. Pediatr Hematol Oncol 2010; 27(8): 597-607.
- El-Beshlawy A, Youssry I, El-Saidi S, El Accaoui R, Mansi Y, Makhlouf A, et al. Pulmonary
hypertension in beta-thalassemia major and the role of L-carnitine therapy. Pediatr Hematol Oncol 2008; 25(8): 734-43.
- Singer ST, Kuypers FA, Styles L, Vichinsky EP, Drucella F, Rosenfeld H. Pulmonary hypertension in thalassemia: Association with platelet activation and hypercoagulable state. Am J Hematol 2006; 81(9): 670-5.
- Morsy MF, Alnajjar AA, Almuzainy IS, Alhawsawi ZM, Alserafi MH, Ahmed AA. Splenectomized versus non-splenectomized patients with thalassemia major. Echocardiographic comparison. Saudi Med J 2008; 29(9): 1310-4.
- Olivieri NF, BrittenhamGM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997; 89(3): 739-61.
- Overmoyer BA, McLaren CE, Brittenham GM. Uniformity of liver density and nonheme (storage) iron distribution. Arch Pathol Lab Med 1971; 111(6): 549-54.
- Grisaru D, Rachmilewitz E A, Mosseri M, Gotsman M, Lafair J S, Okon E, et al. Cardiopulmonary assessment in beta-thalassemia major. Chest 1990; 98(5): 1138-42.
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Sci J Iran Blood Transfus Organ 2018; 15(3): 203-209
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Frequency of Pulmonary Hypertension among patients
with Major Thalassemia in Sanandaj Besat Hospital,
2014-2015
Moradveisi B.1, Shahidi M.1, Vahedi S.1, Yazdanifard P.1, Sohrabi M.2, Naleini N.2
1Besat Hospital, Kurdistan University of Medical Sciences, Sanadaj, Iran
2Kurdistan University of Medical Sciences, Sanadaj, Iran
Abstract
Background and Objectives
Thalassemia syndromes are hereditary disorders of alpha and beta globin band. Nowadays with appropriate treatment for this group of patients, their survival rate has significantly increased. But it has led to new complications like pulmonary hypertension that were not possible events to experience before. This study investigates the frequency of pulmonary arterial hypertension among patients with beta thalassemia.
Materials and Methods
In this descriptive study, pulmonary hypertension was evaluated by echocardiography among 50 patients with beta thalassemia who referred to our Sanandaj University Hospital, Besat during 1393-1394. Demographic and Echocardiographic findings besides lab tests were evaluated and compared between subgroups.
Results
Among 50 participants, 8% had pulmonary hypertension. In subgroups, pulmonary hypertension was found in 15.4% of children, 5.4% of adults, 8.2% of patients with high ferritin, 11.5% of patients with thrombocytosis, and 8.2% of patients who had splenectomy.
Conclusions
Frequency of pulmonary hypertension among our patients is less than previously published studies with higher rate among children. Also the present study showed thrombocytosis and splenectomy as associating factors among thalassemia patients with pulmonary hypertension.
Key words: beta-Thalassemia, Pulmonary Hypertension, Thrombocytosis, Splenectomy
Received: 28 Jan 2018
Accepted: 24 Jul 2018
Correspondence: Yazdanifard P., MD. Pediatric Resident, Besat Hospital, Kurdistan University of Medical Sciences.
Postal Code: 6617967617, Sanandaj, Iran. Tel: (+9887) 33235445; Fax: (+9887) 33232441
E-mail: parinyazdanifard@yahoo.com
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Moradveisi B, Shahidi M, Vahedi S, Yazdanifard P, Sohrabi M, Naleini N. Frequency of Pulmonary Hypertension among patients with Major Thalassemia in Sanandaj Besat Hospital, 2014-2015. Sci J Iran Blood Transfus Organ 2018; 15 (3) :203-209 URL: http://bloodjournal.ir/article-1-1174-en.html
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