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The results of two methods of factor VIII:C in patients with hemophilia A
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F. Vossough Shirayeh   , M. Ahmadinejad , Gh. Toogeh , K. Karimi , M.R. Tabatabaei |
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| Keywords: Key words: Hemophilia A, Factor VIII, Prevalence |
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Full-Text [PDF 233 kb]
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Type of Study: Research |
Subject:
Hematology
Published: 2016/12/24
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Full-Text: (11200 Views) |
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Sci J Iran Blood Transfus Organ 2017; 13(4): 277-283
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The results of two methods of factor VIII:C in patients
with hemophilia A
Vosough Shirayeh F.1, Ahmadinejad M.1, Toogeh Gh.2,3, Karimi K.3, Tabatabaei M.R.1,
Homayoun S.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background and Objectives
FVIII activity (FVIII:C) is measured by clotting or chromogenic methods. The results of these methods may be different in some cases of hemophilia A that can cause misdiagnosis. The Aim of this study is to assess the results of two methods of F VIII:C assay in patients with hemophilia A .
Materials and Methods
In A descriptive survey research, FVIII:C level was measured using one-stage and chromogenic assays in 73 hemophilia A known patients. The data were analyzed by t-test and SPSS 22 statistical method.
Results
From 73 patients in this study, the range of FVIII:C assay by one-stage method was 4% to 81% ( mean = 22.7 , SD = 14.8 ) and the range of FVIII:C assay by chromogenic method was 1% to 123 % ( mean=16.5 , SD = 21 ).
Conclusions
For prevention of misdiagnosis, it is recommended to use two methods of FVIII:C assays for diagnosis of patients with hemophilia A.
Key words: Hemophilia A, Factor VIII, Prevalence
Received: 8 Mar 2016
Accepted: 8 Aug 2016
Correspondence: Ahmadinejad M., MD. Pathologist. Assistant Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88212459; Fax: (+9821) 88601555
E-mail: minooam26@yahoo.com
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Vossough Shirayeh F, Ahmadinejad M, Toogeh G, karimi K, Tabatabaei M. The results of two methods of factor VIII:C in patients with hemophilia A. Sci J Iran Blood Transfus Organ 2016; 13 (4) :277-283 URL: http://bloodjournal.ir/article-1-1028-en.html
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