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:: Volume 13, Issue 4 (Winter 2016) ::
Sci J Iran Blood Transfus Organ 2016, 13(4): 277-283 Back to browse issues page
The results of two methods of factor VIII:C in patients with hemophilia A
F. Vossough Shirayeh , M. Ahmadinejad , Gh. Toogeh , K. Karimi , M.R. Tabatabaei
Abstract:   (4658 Views)

Abstract

Background and Objectives

FVIII activity (FVIII:C) is measured by clotting or chromogenic methods. The results of these methods may be different in some cases of hemophilia A that can cause misdiagnosis. The Aim of this study is to assess the results of two methods of F VIII:C assay in patients with hemophilia A.

Materials and Methods

In A descriptive survey research, FVIII:C level was measured using one-stage and chromogenic assays in 73 hemophilia A known patients. The data were analyzed by t-test and SPSS 22 statistical method. 

Results

From 73 patients in this study,  the range of FVIII:C assay by one-stage method  was 4% to 81% ( mean = 22.7 , SD = 14.8 ) and the range of FVIII:C assay by chromogenic method was 1% to 123 % ( mean=16.5 , SD = 21 ).

Conclusions 

For prevention of misdiagnosis, it is recommended to use two methods of FVIII:C assays for diagnosis of patients with hemophilia A.

Keywords: Key words: Hemophilia A, Factor VIII, Prevalence
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Type of Study: Research | Subject: Hematology
Published: 2016/12/24
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Vossough Shirayeh F, Ahmadinejad M, Toogeh G, karimi K, Tabatabaei M. The results of two methods of factor VIII:C in patients with hemophilia A. Sci J Iran Blood Transfus Organ 2016; 13 (4) :277-283
URL: http://bloodjournal.ir/article-1-1028-en.html


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Volume 13, Issue 4 (Winter 2016) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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