TY - JOUR T1 - A case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K TT - گزارش یک مورد کمبود موقت و اکتسابی فاکتورهای انعقادی وابسته به ویتامین K بدون هیچ‌گونه پاسخ درمانی به تجویز ویتامین K JF - Blood-Journal JO - Blood-Journal VL - 17 IS - 4 UR - http://bloodjournal.ir/article-1-1337-en.html Y1 - 2020 SP - 315 EP - 321 KW - Key words: Vitamin K KW - Menorrhagia KW - Clotting Factor N2 - Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated. Case We present a rare case of 43 year woman with acquired vitamin K deficiency and severe menorrhagia without any gynecological problem. The level of all Vitamin-K dependent coagulation factors, Fctor II, Factor VII, Factor IX, and Factor X decreased. Furthermore, even after multiple administration of Vitamin K and its oral consumption, still the level of coagulation factors and menorrhagia did not ameliorate. Conclusions Acquired VKCFD is one of the rare situations that can be life-threatening. M3 ER -