Abstract

 Background and Objectives

 HLA system plays a key role in the cancer cells’escape from the immune surveillance. AML is a cancer of the myeloid lines of blood cells, characterized by the rapid growth of abnormal white blood cells in the bone marrow. Several studies worldwide have investigated the association of AML with alleles of HLA. This study was performed to assess the association between alleles of HLA-A, -B,-DRB1 with AML patients in Kerman province of Iran.

 Materials and Methods

 In the present case control study, alleles of HLA-A, -B, -DRB1 were molecularly typed using PCR-SSP technique in 33 AML patients and 270 healthy individuals unrelated with patients in province of Kerman, Iran. Finally, the data analysis was performed using c ² and SPSS 19.

 Results

 In this study, allelic frequency rates of HLA-A*11 in patient and control groups were 28.8% (19 cases) and 17% (92 cases), respectively it indicates a significantly positive association between the presence of this allele and AML illness (p = 0.02, OR = 1.97 and CI (95%) = 1.10-3.51).

 Conclusions

 The presence of HLA-A* 11 in AML patients may be a predisposing factor for this disease to develop.