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:: Volume 12, Issue 2 (Summer 2015) ::
Sci J Iran Blood Transfus Organ 2015, 12(2): 173-178 Back to browse issues page
The Prevalence of Yersinia Yop-specific IgA antibodies in Iranian blood donors evaluated by specific serology and blood culture methods
H. Timori Naghadeh , A. Dabir Moghaddam , Z. Pirmohammad Jamaat , R. Sharifi
Abstract:   (5386 Views)

  Abstract

 Background and Objectives

 The recomwell Yesinia uses YOPs (Yesinia outer membrane proteins) produced by recombinant techniques that are highly specific for the genus Yersinia. The aim of this study is to determine the prevalence of Yesinia Yop-specific IgA antibodies in 492 healthy blood donors and make comparison between seropositivity and the presence of y.enterocolitica infection in blood donors.

 

 Materials and Methods

 In the descriptive study, sera from 492 healthy Iranian blood donors were studied for Yesinia Yop-specific IgA antibodies by two different techniques, enzyme immunoassay (EIA) and western blot to determine the prevalence of Yersinia antibody. Secondly, we cultured the whole blood of Yesinia seropositive donors which has been stored in 1-6C for 35 days. Thirdly, we compared the rate of seropositivity with the results of donors’ blood cultures.

  

 Results

 The prevalence rates of Yesinia Yop-specific IgA antibodies in Tehran healthy blood donors were 12.5% and 8.5% by EIA and Western Blot, respectively. The blood cultures of all seropositive donors were negative.

 

 Conclusions

 Although the prevalence rate of Yesinia Yop-specific IgA antibodies in Iranian healthy blood donors was high there was no correlation whatsoever between seropositivity and donors’ bacteremia.

 

Keywords: Key words : Yersinia enterocolitica, Septicemia, Blood Donors
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Type of Study: Research | Subject: Blood Transfusion
Published: 2015/07/5
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Timori Naghadeh H, Dabir Moghaddam A, Pirmohammad Jamaat Z, Sharifi R. The Prevalence of Yersinia Yop-specific IgA antibodies in Iranian blood donors evaluated by specific serology and blood culture methods. Sci J Iran Blood Transfus Organ 2015; 12 (2) :173-178
URL: http://bloodjournal.ir/article-1-867-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 12, Issue 2 (Summer 2015) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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