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:: Volume 10, Issue 1 (Spring 2013) ::
Sci J Iran Blood Transfus Organ 2013, 10(1): 86-92 Back to browse issues page
Evaluation of cardiac function in patients with major beta thalassemia in Birjand
T. Chahkandi , T. Kazemi , A. Jalili , F. Ghaderi
Abstract:   (14252 Views)

  Abstract

 Background and Objectives

 The most common leading causes of death in patients with major beta thalassemia are cardiac complications.The purpose of this study is to determine cardiac function in patients with major thalassemia in Birjand.

 

 Materials and Methods

 This descriptive-analytical study was conducted on all patients with major beta thalassemia having referred to special clinics of Valiasr Hospital in Birjand. Variables such as age, sex, frequency of transfusions, serum ferritin, and hemoglobin were studied. For all patients after a thorough examination of heart, ECG, chest X-ray, and echocardiography were performed. All data were collected and analyzed with SPSS software 15.5 by t-test at α ≤ 0.05.

  

 Results

 We studied 35 patients with major beta thalassemia. The mean age was 9.06 ± 4.33 years. The mean hemoglobin was 9.2 gr/dl and the mean ferritin 2121.6 ng/ml, respectively. Cardiac examinations showed 62.9% of patients to be normal. ECG and chest X-ray in 71.6% and 57.1% of patients were normal, respectively. Out of the total number of patients, 77.8% had abnormal echocardiography. The most common abnormal findings in echocardiography were restrictive diastolic dysfunction. No significant correlation was found between abnormal findings on echocardiography with both ferritin and the number of blood transfusions. However, left ventricular diastolic dysfunction and hemoglobin were not significantly associated (8.5 ± 0.69 gr/dL in normal diastolic function, 9.6 ± 0.99 gr/dL in diastolic dysfunction p= 0.007).

  

 Conclusions

 The most common finding in our study was left ventricular diastolic dysfunction. Therefore, periodic echocardiography to determine the risk of heart involvement is very valuable.

  

 

Keywords: Key words: beta-Thalassemia, Electrocardiography, Radiography, Echocardiography
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Type of Study: Research | Subject: Hematology
Published: 2013/08/14
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Chahkandi T, Kazemi T, Jalili A, Ghaderi F. Evaluation of cardiac function in patients with major beta thalassemia in Birjand. Sci J Iran Blood Transfus Organ 2013; 10 (1) :86-92
URL: http://bloodjournal.ir/article-1-742-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 1 (Spring 2013) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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