Myocardial infarction (MI) is one of the most important causes of death in the world. The platelets play an important role in ischemic myocardial disease in many ways after a brief episode of ischemia, oxygen-derived free radicals are generated in several pathological processes. Oxidation of platelet enzymes such as xanthine oxidase and lipid peroxidation may increase after MI.
Materials and Methods
In this cross-sectional study, we have studied 20 patients with MI (group1) and 10 voluntary healthy people as the normal control (group 2) for 10 months. Group1 just recieved routine drugs ( β -blockers) and aspirin, while group 2 received an extra vitamin E for 6 days. We collected 10 ml coagulated blood from patients and controls. After preparation of the platelet-rich plasma (PRP), xanthine oxidase and lipid peroxidase of platelets were detected. Data were analyzed by using SPSS16, paired T- test and ANOVA test.
Results
Findings showed that the administration of vitamin E along with aspirin after 6 days brought about a good antioxidant drugs effect as evidenced by the activity reduction of platelet xanthine oxidase (p< 0.001) and decrease of lipid peroxidase metabolite (p< 0.001).
Conclusions:
Using vitamin E along with the other β -blocker drugs would protect patients with MI from oxidant and further heart failure.
Hamidpour M, Saiidi K, Taslimi R, Khadem Maboudi A, Gharehbaghian A. Detection of the effect of anti-oxidant drugs on platelet xanthine oxidase and lipid peroxidase in the patients with myocardials infraction . Sci J Iran Blood Transfus Organ 2012; 9 (3) :300-307 URL: http://bloodjournal.ir/article-1-684-en.html