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:: Volume 5, Issue 2 (Summer 2008) ::
Sci J Iran Blood Transfus Organ 2008, 5(2): 117-123 Back to browse issues page
Cytogenetic study of prognostic determinants in children with acute lymphoblastic leukemia
Sh. Nazari , A. Shafiei , F. Abdollah Gorji
Abstract:   (16495 Views)

  Abstract

 Background and Objectives

 Acute lymphoblastic leukemia though the most frequent malignancy in children has well responded to medical treatment as compared with other types of malignancies in recent years. In addition to age, sex and number of white blood cells, genetic survey has been one of the prognostic determinants. This research has been carried out on children diagnosed after being referred to Mofid Children Hospital during a period of three years. This study aims at determining the factors effective on prognosis of lymphoblastic leukemia with an emphasis on patient acute karyotype.

 

 Materials and Methods

 Out of 102 patients with the diagnosis of acute lymphoblastic leukemia being referred to this hospital between 1990-2002, 74 (within the age groups varying from 6 months to 13 years old) underwent cytogenetic test out of the latter 28 were excluded. These 74 were classified according to their WBC count and age into high (42 cases) and low risk groups (32 cases). Then, the results were analyzed and compared according to the subfactors such as flowcytometry, age, sex, and blood cell count (WBC, hemoglobin and platelet) both in high and low risk groups.

 

 Results

 From 74 cases under study, flowcytometry showed that 64 (86.5%) suffered from leukemia type pre B cell out of the latter 38 (59.4%) based on the number of white cells were placed in the low-risk group. In cytogenetic survey, 34 (45.9%) patients had normal karyotype, 16 (21.6%) had abnormality of chromosome number, and 14 (19%) abnormality of chromosomal structure. No conclusion could be drawn from cytogenetic test conducted on the remaining 10 cases. Comparison of the two groups of high and low risk showed no significant differences. From gender point of view, number of boys was considerably higher than girls in the low risk group (61.9% vs. 39.1%). But as far as karyotype was concerned, there were no differences between the two groups.

 

 Conclusions

 Regarding the research findings, there was no significant difference between the two groups from genetic disorders point of view. Accordingly, we can conclude that age and number of WBC by themselves are not suitable preliminary factors for prognosis and genetic determination in genes domain. So, it seems necessary for a similar research at a larger scale to be conducted in which prognostic determinants are complied with disease trend.

 

 Key words : Acute lymphoblastic leukemia, Cytogenetic, Prognosis

 

Keywords: Acute lymphoblastic leukemia, Cytogenetic, Prognosis
Full-Text [PDF 212 kb]   (2500 Downloads)    
Type of Study: Research | Subject: Hematology
Published: 2014/08/17
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Nazari S, Shafiei A, Abdollah Gorji F. Cytogenetic study of prognostic determinants in children with acute lymphoblastic leukemia. Sci J Iran Blood Transfus Organ 2008; 5 (2) :117-123
URL: http://bloodjournal.ir/article-1-239-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5, Issue 2 (Summer 2008) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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