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:: Volume 14, Issue 3 (Atumn 2017) ::
Sci J Iran Blood Transfus Organ 2017, 14(3): 237-248 Back to browse issues page
The Application of Mesenchymal Stem Cell-Derived Vesicles in Regenerative Medicine
D. Pashoutan Sarvar , K. Shamsasenjan , P. Akbarzadehlaleh , A.A. Movassaghpour , Hamze Timari , Sara Aqmasheh
Keywords: Key words: Regenerative Medicine, Cell Therapy, Mesenchymal Stem Cells, Extracellular Vesicles
Full-Text [PDF 351 kb]   (4747 Downloads)     |   Abstract (HTML)  (5770 Views)
Type of Study: Review Article | Subject: Stem cells
Published: 2017/09/12
Full-Text:   (4140 Views)
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Sci J Iran Blood Transfus Organ 2017; 14(3): 237-248
Review  Article
 

 

The Application of Mesenchymal Stem Cell-Derived
Vesicles in Regenerative Medicine
 
Pashoutansarvar D.1, Shamsasenjan K. 2, Akbarzadehlaleh P.3, Movassaghpour A.A.2,
Timari H.1, Aqmasheh S.1
 
 
1Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
 
 
Abstract
Background and Objectives
Mesenchymal stem cells are pluripotent cells characterized by self-renewal and the stromal multilineage differentiation potency. These cells play an important role in tissue homeostasis through direct cell-cell interaction and release of various growth factors and cytokines. Vesicles derived from mesenchymal stem cells rich in various growth factors such as proteins, cytokines and microRNAs are produced under different physiological or pathological conditions. Differentiation capability of these vesicles in repairing damaged tissues, as well as immune response modulation, has caused the vesicles to be considered as useful and efficient tools in regenerative medicine.
 
Materials and Methods
In the present review study, the authors investigated many articles over the past two decades published on the isolation and characterization of vesicles derived from mesenchymal stem cells, as well as on the application of these vesicles in regenerative medicine.
 
Results
The review of various articles showed that mesenchymal stem cells exert their paracrine effects by secreting different cytokines and vesicles. Mesenchymal stem cell-derived vesicles have protective effects such as regenerating damaged tissues, angiogenesis, neurogenesis, suppression of inflammatory reactions and modulation of immune responses.
 
Conclusions 
Since the vesicles derived stem cells are supplemented with various growth factors and have tissue repairing potency, these vesicles can be used to repair the damaged tissues. In addition, these vesicles can be used as carriers of drugs or genes.
 
Key words: Regenerative Medicine, Cell Therapy, Mesenchymal Stem Cells, Extracellular Vesicles
 
 
 
 
 
Received:  13 Nov 2016
Accepted: 11 Jul  2017
 
 

Correspondence: Shams Asenjan K., PhD of Hematology and Blood Banking. Assistant Professor of Hematology and Oncology Research Center, Tabriz University of Medical Sciences.
P.O.Box: 51335, Tabriz, Iran. Tel: (+98411) 2871515; Fax: (+98411) 2871515
E-mail: k.shams@ibto.ir
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Pashoutan Sarvar D, Shamsasenjan K, Akbarzadehlaleh P, Movassaghpour A, Timari H, Aqmasheh S. The Application of Mesenchymal Stem Cell-Derived Vesicles in Regenerative Medicine. Sci J Iran Blood Transfus Organ 2017; 14 (3) :237-248
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فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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