Abstract

Background and Objectives

SR-B1 acts as the main receptor for HDL and plays an important role in reverse cholesterol transport. In contrast to LDL level which causes Atherosclerotic plaque in artery, plasma concentration of HDL correlates inversely with the incidence of coronary artery disease and atherosclerosis. This study investigates the expression of Scavenger Receptor-B1 and its role on the function of platelets in patients with atherosclerotic disease.

Materials and Methods

The present case-control study evaluated the SR-B1 receptor of 24 patients with atherosclerotic plaque and 24 healthy volunteers as the normal control. After separation of platelet, the expression of SR-BI was detected using western blotting. Platelet function in response to agonists was examined by aggregometry. Finally, the data were statistically analyzed using SPSS version 16 software and the student T-test.

Results

The western blotting assay showed a significant reduction of SR-BI protein expression in AD patients (0.4 AU) compared with the healthy control (1.4 AU), (p < 0.001). The platelet aggregation in response to ADP showed a significant increase in patients (85%) compared to the control (51%), (p < 0.001).

Conclusions 

The levels of SR-B1expression correlate inversely with platelet aggregation.